The article you requested is
Single-Dose Intravenous Valproate in Acute Mania.
J Clin Psychiatry 2004;65:68-70
Copyright 2004 Physicians Postgraduate Press, Inc.
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Objective: High-dose loading with oral and
intravenous valproate has been reported to be therapeutic in
mania over 48 to 72 hours. We hypothesized that very high dose
intravenous (IV) valproate might have even more rapid effects
equivalent to effects in status epilepticus that occur within 20
Method: Seven patients with mania (Young Mania
Rating Scale score > 20) and minimal prior drug treatment were
given valproate 20 mg/kg IV over 30 minutes.
Results: No antimanic effects were observed
during 120 minutes of observation. There were no side effects.
Conclusion: Slowly evolving biochemical changes,
perhaps at the gene level, may be required for the antimanic
effect of anticonvulsants.