The article you requested is
Academic Highlights: New Insights Into Genetics and Pathophysiology of Alzheimer's Disease: What Are the Clinical and Therapeutic Implications?
J Clin Psychiatry 2000;61:307-315
Copyright 2000 Physicians Postgraduate Press, Inc.
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Genetic findings have made an
important contribution to the understanding
of Alzheimer’s disease. The
mutations in β-amyloid precursor protein
(βAPP) and presenilin 1 (PS1)
transmitted in a simple Mendelian manner
have provided the basis for our
understanding of the central role of
β-amyloid in all cases of Alzheimer’s.
Dr. Mullan suggested that whereas
variability at the apolipoprotein E
(APOE) locus is clearly associated with
the occurrence of disease, for many
other genes such clarity is less established.