10002720 J Clin Psychiatry / Document Archive

Psychiatrist.com Home    Keyword Search

Close [X]

Search Our Sites

Enter search terms below (keywords, titles, authors, or subjects). Then select a category to search and press the Search button. All words are assumed to be required. To search for an exact phrase, put it in quotes. To exclude a term, precede it with a minus sign (-).

Keyword search:

Choose a category:

Choosing the appropriate category will greatly improve your chances of finding the best match.

All files at our sites: J Clin Psychiatry, Primary Care Companion, CME Institute, and MedFair

Search materials from our journals:

Abstracts from The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements

PDFs of the full text of The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements (Net Society Platinum [paid subscribers])

PDFs of the full text of The Primary Care Companion to The Journal of Clinical Psychiatry, 1999–present

Search CME offerings:

CME Institute, including CME from journals , supplements, and Web activities for instant CME credit (Net Society Gold [registered users]); also includes information about our CME program

CME activities from regular issues of The Journal of Clinical Psychiatry (Net Society Gold [registered users])

CME Supplements from The Journal of Clinical Psychiatry (Net Society Gold [registered users])

 

The article you requested is

Association Study of the 5-HTTLPR Polymorphism and Depression in 75-Year-Old Nondemented Subjects From the Vienna Transdanube Aging (VITA) Study.

J Clin Psychiatry 2006;67:1373-1378
Copyright 2006 Physicians Postgraduate Press, Inc.

To view this item, select one of the options below.

  1. NONSUBSCRIBERS
    1. Purchase this PDF for $30
      If you are not a paid subscriber, you may purchase the PDF.
      (You'll need the free Adobe Acrobat Reader.)
    2. Subscribe
      Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($129) or print + online ($166 individual).
    3. Celebrate JCP's 75th Anniversary with a special online-only subscription price of $75.
  2. PAID SUBSCRIBERS
    1. Activate
      If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
    2. Sign in
      As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
  1. Did you forget your password?

Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send an email

| 67.202.4.225

Background: The site of effect for the selective serotonin reuptake inhibitors (SSRIs) is the serotonin transporter (5-HTT), which is extensively investigated for its involvement in depressive symptoms. The 5-HTT gene exhibits a 5'-promoter-based length polymorphism (5-HTTLPR) that affects the transcription efficiency and activity, known as short (S) and long (L) alleles. We studied the association of this polymorphism in old age and depression in the Vienna Transdanube Aging (VITA) study, excluding subjects with dementia.

Method: We used retrospective data from the baseline of the VITA study, which is a cohort study of all inhabitants of a geographical area aged 75 years (N = 544). Depression was diagnosed and classified strictly according to the DSM-IV. To eliminate dementia effects, we excluded subjects with a Clinical Dementia Rating higher than or equal to 1 and/or a Mini-Mental State Examination score lower than 24. Genotyping for the 5-HTTLPR L/S allele was conducted using polymerase chain reaction methodology.

Results: We found significantly higher SS genotype frequency in all subjects with past/present depression compared to controls (trend test, p = .01). The SS genotype frequency was especially high in subjects with onset of depression before age 65. No correlations were found between genotypes/S allele carriers and actual Hamilton Rating Scale for Depression, Short-Geriatric Depression Scale, and anxiety scale scores.

Conclusions: These observations of higher frequency of the 5-HTTLPR S allele in subjects with past/present depression fit with previous findings and point to the important role of 5-HTT in depression.