10003207 J Clin Psychiatry / Document Archive

Psychiatrist.com Home    Keyword Search

Close [X]

Search Our Sites

Enter search terms below (keywords, titles, authors, or subjects). Then select a category to search and press the Search button. All words are assumed to be required. To search for an exact phrase, put it in quotes. To exclude a term, precede it with a minus sign (-).

Keyword search:

Choose a category:

Choosing the appropriate category will greatly improve your chances of finding the best match.

All files at our sites: J Clin Psychiatry, Primary Care Companion, CME Institute, and MedFair

Search materials from our journals:

Abstracts from The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements

PDFs of the full text of The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements (Net Society Platinum [paid subscribers])

PDFs of the full text of The Primary Care Companion to The Journal of Clinical Psychiatry, 1999–present

Search CME offerings:

CME Institute, including CME from journals , supplements, and Web activities for instant CME credit (Net Society Gold [registered users]); also includes information about our CME program

CME activities from regular issues of The Journal of Clinical Psychiatry (Net Society Gold [registered users])

CME Supplements from The Journal of Clinical Psychiatry (Net Society Gold [registered users])

 

The article you requested is

A Systematic Review of Placebo Response in Studies of Bipolar Mania.

J Clin Psychiatry 2007;68:1213-1217
Copyright 2007 Physicians Postgraduate Press, Inc.

To view this item, select one of the options below.

  1. NONSUBSCRIBERS
    1. Purchase this PDF for $40
      If you are not a paid subscriber, you may purchase the PDF.
      (You'll need the free Adobe Acrobat Reader.)
    2. Subscribe
      Receive immediate full-text access to JCP. You can subscribe to JCP print + online for $166 individual.
      JCP's 75th AnniversaryCelebrate!
      Celebrate JCP's 75th Anniversary with a special online-only subscription price of $75.
  2. PAID SUBSCRIBERS
    1. Activate
      If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
    2. Sign in
      As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
  1. Did you forget your password?

Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send an email

| 54.90.49.181

Objective: In a previous review, we found that response to placebo in studies of major depression was increasing over time. The purpose of this study was to examine placebo response rates in trials of acute bipolar mania.

Data Sources: We searched MEDLINE for placebo-controlled trials in which patients with bipolar mania were randomly assigned to receive medication or placebo. Searches included combinations of the terms acute bipolar mania, placebo-controlled, double-blind, randomized, and common medication names (e.g., lithium, risperidone). In addition, reference lists from identified articles and any reviews of bipolar mania were examined. The search was limited to literature in English, published between January 1980 and November 2005.

Study Selection: The review identified 21 studies published between 1991 and 2005. Twenty studies used a response criterion of a 50% or greater decrease on the Young Mania Rating Scale (YMRS) or Mania Rating Scale (MRS), or a designation of much or very much improved on the Clinical Global Impressions-Improvement scale (CGI, score of 1 or 2).

Data Extraction: Data were extracted from the articles by one of the authors (R.S.) and all of the data used in the analyses were verified by the other author (B.T.W.).

Data Synthesis: Pearson correlation coefficients (2-tailed) and linear regression were used to examine the strength of the relationship between continuous variables. There was a significant association between the year of publication and placebo response rate in studies using the YMRS (N = 14) (r = 0.545, p = .04); however, when data from studies using the CGI and MRS were added, the association was no longer significant (r = 0.374, N = 20, p = .10).

Conclusions: The response rate to placebo in studies of bipolar mania (31.2%) was similar to the rate observed in major depression (29.7%). Over a limited number of years, there was some indication of a change in placebo response on the YMRS in studies of bipolar mania; however, the small number of studies available for analysis limits our ability to draw definitive conclusions.