The article you requested is
Academic Highlights: A Roadmap to Key Pharmacologic Principles in Using Antipsychotics in the Treatment of Bipolar Disorder
J Clin Psychiatry 2008;69:1176-1183
Copyright 2008 Physicians Postgraduate Press, Inc.
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On the basis of the National
Comorbidity Survey Replication
(NCS-R), it is estimated that bipolar I
and II disorders may affect nearly 3%
of the population (i.e., 5.7 million
Americans), with the prevalence of
subthreshold but still impairing bipolar
presentations estimated to be even
higher. Bipolar disorder is associated
with significant functional impairment
and elevated health care costs. Although
unipolar depression appears to
be over 6 times as prevalent as bipolar
disorder, NCS-R data found that the
costs of bipolar disorder to the U.S.
workplace, estimated at $14.1 billion
annually, were almost half the cost of
lost productivity associated with unipolar