10003721 J Clin Psychiatry / Document Archive

Psychiatrist.com Home    Keyword Search

Close [X]

Search Our Sites

Enter search terms below (keywords, titles, authors, or subjects). Then select a category to search and press the Search button. All words are assumed to be required. To search for an exact phrase, put it in quotes. To exclude a term, precede it with a minus sign (-).

Keyword search:

Choose a category:

Choosing the appropriate category will greatly improve your chances of finding the best match.

All files at our sites: J Clin Psychiatry, Primary Care Companion, CME Institute, and MedFair

Search materials from our journals:

Abstracts from The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements

PDFs of the full text of The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements (Net Society Platinum [paid subscribers])

PDFs of the full text of The Primary Care Companion to The Journal of Clinical Psychiatry, 1999–present

Search CME offerings:

CME Institute, including CME from journals , supplements, and Web activities for instant CME credit (Net Society Gold [registered users]); also includes information about our CME program

CME activities from regular issues of The Journal of Clinical Psychiatry (Net Society Gold [registered users])

CME Supplements from The Journal of Clinical Psychiatry (Net Society Gold [registered users])

 

The article you requested is

Sex- and Age-Specific Incidence of Fractures in Mental Illness: A Historical, Population-Based Cohort Study

J Clin Psychiatry 2008;69:1398-1403
Copyright 2008 Physicians Postgraduate Press, Inc.

To view this item, select one of the options below.

  1. NONSUBSCRIBERS
    1. Purchase this PDF for $30
      If you are not a paid subscriber, you may purchase the PDF.
      (You'll need the free Adobe Acrobat Reader.)
    2. Subscribe
      Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($129) or print + online ($166 individual).
  2. PAID SUBSCRIBERS
    1. Activate
      If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
    2. Sign in
      As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
  1. Did you forget your password?

Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send an email

| 54.204.217.249

Objective: To estimate risks of fracture at any site, and at sites linked with osteoporosis, in mentally ill adults compared with the general population.

Method: We created a community-based cohort by using the U.K. General Practice Research Database, with follow-up from January 1987 through April 2005. We investigated age- and sex-specific fracture risks in psychotic illness (N = 4283), nonpsychotic affective disorder (N = 95,228), and any other psychiatric condition (N = 49,439). Comparison cases were subjects with no psychiatric code (N = 182,851); age-stratified (18-44 years, 45-74 years, >= 75 years) relative risks (RRs) were estimated by Poisson regression. Outcomes were incident cases of fracture at any site, at the hip, and at the distal radius.

Results: Among all mentally ill women, highest RRs of fracture at any site were in the youngest age group, whereas the strongest effects in men were with older age. The highest raised risk of any fracture occurred in premenopausal women with psychotic disorders (RR = 2.5, 95% CI = 1.5 to 4.3). Hip fracture rates were raised in elderly women and men with psychiatric illness and were especially high in women (RR = 5.1, 95% CI = 2.7 to 9.6) and men (RR = 6.4, 95% CI = 2.6 to 16.1) with psychotic disorders at ages 45 to 74 years. Data were too sparse to estimate RR of distal radius fracture, although risk was modestly (but significantly) higher among women with any mental illness in each age group than the reference population, i.e., women with no history of psychiatric disorder.

Conclusion: Raised risks of fracture in mental illness are likely to be explained by a range of mechanisms. Further research is needed to elucidate these mechanisms and to inform the development of targeted interventions.