The article you requested is
High-Dose Olanzapine Versus Clozapine
J Clin Psychiatry 2008;69:1660-1660 [letter]
Copyright 2008 Physicians Postgraduate Press, Inc.
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Letter to the Editor
Sir: The article by Meltzer and colleagues1 suggesting
that high-dose olanzapine may be equivalent to clozapine in
treatment-resistant schizophrenics warrants some discussion.
The authors’ power analysis suggested that 17 patients per
group would be sufficient to provide 80% power. However, the
power analysis (as is often the case) did not consider dropouts,
and this was a particular concern in this study since 6 of 21 patients
receiving clozapine dropped out prior to 6 weeks.