10003860 J Clin Psychiatry / Document Archive

Psychiatrist.com Home    Keyword Search

Close [X]

Search Our Sites

Enter search terms below (keywords, titles, authors, or subjects). Then select a category to search and press the Search button. All words are assumed to be required. To search for an exact phrase, put it in quotes. To exclude a term, precede it with a minus sign (-).

Keyword search:

Choose a category:

Choosing the appropriate category will greatly improve your chances of finding the best match.

All files at our sites: J Clin Psychiatry, Primary Care Companion, CME Institute, and MedFair

Search materials from our journals:

Abstracts from The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements

PDFs of the full text of The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements (Net Society Platinum [paid subscribers])

PDFs of the full text of The Primary Care Companion to The Journal of Clinical Psychiatry, 1999–present

Search CME offerings:

CME Institute, including CME from journals , supplements, and Web activities for instant CME credit (Net Society Gold [registered users]); also includes information about our CME program

CME activities from regular issues of The Journal of Clinical Psychiatry (Net Society Gold [registered users])

CME Supplements from The Journal of Clinical Psychiatry (Net Society Gold [registered users])

 

The article you requested is

Predictors of Nonadherence to Continuation and Maintenance Antidepressant Medication in Patients With Remitted Recurrent Depression

J Clin Psychiatry 2009;70(1):63-69
10.4088/JCP.08m04119
Copyright 2008 Physicians Postgraduate Press, Inc.

To view this item, select one of the options below.

  1. NONSUBSCRIBERS
    1. Purchase this PDF for $30
      If you are not a paid subscriber, you may purchase the PDF.
      (You'll need the free Adobe Acrobat Reader.)
    2. Subscribe
      Receive immediate full-text access to JCP. You can subscribe to JCP online-only ($129) or print + online ($166 individual).
    3. Celebrate JCP's 75th Anniversary with a special online-only subscription price of $75.
  2. PAID SUBSCRIBERS
    1. Activate
      If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
    2. Sign in
      As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
  1. Did you forget your password?

Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send an email

| 54.196.57.4

Objective: To identify predictors of nonadherence to continuation and maintenance antidepressant medication among patients with remitted recurrent depression.

Method: We used data of 91 remitted, recurrently depressed patients (at least 2 major depressive episodes as assessed by the Structured Clinical Interview for DSM-IV Axis I Disorders) treated with continuation and maintenance antidepressant medication in a 2-year prospective study. Patients were recruited at psychiatric centers and through media announcement from February 2000 through September 2000. Adherence was assessed with the Medication Adherence Questionnaire. Nonadherence on this scale indicates that patients missed 20% or more of their antidepressant medication. We determined nonadherence point prevalences at the 7 assessment points. Based upon these 7 assessments, we found nonadherence percentages ranging from 39.7% to 52.7% with a mean of 46.5% over 2 years. We examined a set of potential risk factors (patient-related, disease-related, and treatment-related) measured at baseline.

Results: In univariate analysis using a stringent significance level (p ≥.005), we found no independently related predictors of nonadherence over a 2-year period. In a multivariate analysis with backward elimination, the baseline predictors for nonadherence over a 2-year period were a higher level of personality pathology and a higher level of education.

Conclusion: There are no clear predictors of nonadherence to antidepressants in the continuation and maintenance phases in remitted, recurrently depressed patients. Further research should focus on the process of becoming nonadherent to antidepressants in the longest phase of antidepressant use to maximize the potential protective effect of these medications.