The article you requested is
Academic Highlights: Controversies in the Diagnosis and Treatment of Severe Depression
J Clin Psychiatry 1996;57:554-561
Copyright 1996 Physicians Postgraduate Press, Inc.
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Severe depression is a frequently diagnosed
disorder and a major health
problem in the United States and Europe.
An international panel of experts
met recently in New Paltz, New York,
to discuss whether severe depression
constitutes a distinct form of depression
and to review effective treatments for
the disorder. In his opening remarks,
Roger Pinder, Ph.D., D.Sc., Medical Director CNS at N.V. Organon, said,
“Severe depression is a major topic for
discussion at the present time. There is
a feeling, with some evidence, that patients
with this disorder respond less
well to SSRIs, suggesting that severe
depression may be better served by using
drugs like the tricyclic antidepressants
or drugs that have a dual mechanism