The article you requested is
Drug Craving and Other Negative Reactions After Abrupt Substitution of Nefazodone for Other Serotonergic Agents
J Clin Psychiatry 1996;57:486-487 [letter]
Copyright 1996 Physicians Postgraduate Press, Inc.
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Letter to the Editor
Sir: Nefazodone is a relatively new antidepressant medication
with a novel profile of neurochemical effects: potent blockade
of the 5-HT2A receptor, inhibition of the serotonin reuptake
pump at higher concentrations, and transient norepinephrine reuptake
inhibition. Among the potential consequences of this
profile include antidepressant and anxiolytic efficacy and decreased
incidence of medication-related complaints of insomnia
and anxiety. Given its reputed lack of sexual side effects, nefazodone
is now regarded as a particularly useful option in cases
where these side effects interfere with patient satisfaction and
compliance with treatment.