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Dr Corruble and Colleagues Reply
Letter to the Editor
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The aim of the bereavement exclusion E criterion for major depressive episode (MDE) is to discriminate subjects with a modest “normal” depressive syndrome that should not be medicalized prematurely.
Our results, in line with previous ones, actually show that this criterion has a poor discriminant validity in treatment-seeking individuals. Indeed, among 11,510 individuals with depressive symptoms, matched subjects fulfilling the MDE A, B, C, and D criteria, and differing only on the presence/absence of the E criterion based on the clinician’s judgment, were not different in terms of 6-week outcome.