10007785 J Clin Psychiatry / Document Archive

Psychiatrist.com Home    Keyword Search

Close [X]

Search Our Sites

Enter search terms below (keywords, titles, authors, or subjects). Then select a category to search and press the Search button. All words are assumed to be required. To search for an exact phrase, put it in quotes. To exclude a term, precede it with a minus sign (-).

Keyword search:

Choose a category:

Choosing the appropriate category will greatly improve your chances of finding the best match.

All files at our sites: J Clin Psychiatry, Primary Care Companion, CME Institute, and MedFair

Search materials from our journals:

Abstracts from The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements

PDFs of the full text of The Journal of Clinical Psychiatry, 1996–present, both regular issues and supplements (Net Society Platinum [paid subscribers])

PDFs of the full text of The Primary Care Companion to The Journal of Clinical Psychiatry, 1999–present

Search CME offerings:

CME Institute, including CME from journals , supplements, and Web activities for instant CME credit (Net Society Gold [registered users]); also includes information about our CME program

CME activities from regular issues of The Journal of Clinical Psychiatry (Net Society Gold [registered users])

CME Supplements from The Journal of Clinical Psychiatry (Net Society Gold [registered users])

 

The article you requested is

Clozapine-Induced Agranulocytosis in Finland, 1982–2007: Long-Term Monitoring of Patients Is Still Warranted

J Clin Psychiatry 2012;73(6):837-842
10.4088/JCP.11m07244
Copyright 2012 Physicians Postgraduate Press, Inc.

To view this item, select one of the options below.

  1. NONSUBSCRIBERS
    1. Purchase this PDF for $40
      If you are not a paid subscriber, you may purchase the PDF.
      (You'll need the free Adobe Acrobat Reader.)
    2. Subscribe
      Receive immediate full-text access to JCP. You can subscribe to JCP print + online for $166 individual.
      JCP's 75th AnniversaryCelebrate!
      Celebrate JCP's 75th Anniversary with a special online-only subscription price of $75.
  2. PAID SUBSCRIBERS
    1. Activate
      If you are a paid subscriber to JCP and do not yet have a username and password, activate your subscription now.
    2. Sign in
      As a paid subscriber who has activated your subscription, you have access to the HTML and PDF versions of this item.
  1. Did you forget your password?

Still can't log in? Contact the Circulation Department at 1-800-489-1001 x4 or send an email

| 54.90.231.18

Objective: Recent studies suggest that restrictions on the use of clozapine should be reassessed considering the risk-benefit ratio. We analyzed all cases of clozapine-induced agranulocytosis reported to the Finnish National Agency for Medicines between 1982 and 2007.

Method: In this retrospective longitudinal study, we defined agranulocytosis as a neutrophil count below 0.5 × 109/L and, accordingly, identified a total of 163 patients with clozapine-induced agranulocytosis. We collected all available information on patient demography, as well as on daily clozapine doses, treatment duration, concomitant medication prior to the onset of agranulocytosis, and infections during the adverse event. The amount of clozapine used annually in Finland was estimated on the basis of the defined daily dose, and the frequency of agranulocytosis was calculated from the absolute number of cases in relation to the defined daily dose each year, as reported by the Finnish National Agency for Medicines.

Results: In 10.3% of cases, agranulocytosis occurred after the second treatment year, and, in some patients, agranulocytosis occurred even after 13, 14, and 22 years of clozapine treatment. Strikingly, a total of 40% of all patients and 80% of those with fatal agranulocytosis had received, concomitantly with clozapine, other medication associated with agranulocytosis.

Conclusions: Some restrictions and long-term blood monitoring during the use of clozapine are still needed. In addition, we raise the question of whether guidelines for concomitant use of drugs associated with agranulocytosis during clozapine therapy are warranted.

J Clin Psychiatry

Submitted: July 4, 2011; accepted October 14, 2011.

Online ahead of print: March 6, 2012 (doi:10.4088/JCP.11m07244).

Corresponding author: Liisa Lahdelma, MD, PhD, Department of Psychiatry, University of Helsinki, PL 590, FI-00029 HUS, Finland (liisa.lahdelma@kolumbus.fi).