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Commentary: Depression and Risk of Dementia: Exploring the Interface
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Neuropsychiatric symptoms have not been part of the defining diagnostic criteria of dementia or mild cognitive impairment (MCI), but their characterization and importance in the preclinical stages of Alzheimer’s disease and presentation of prodromal states such as MCI and potential conversion to dementia continue being established. Subjects progressing to dementia have a higher prevalence of psychopathology than those who remain stable or improve, and thus neuropsychiatric symptoms appear to be a predictor of progression to dementia alongside established factors such as apolipoprotein E (APOE) ε4 carrier status, features of memory function, cerebrospinal fluid Aβ/tau ratio, amyloid imaging, and magnetic resonance imaging volumetric measurements of the hippocampal formation.
Depression and cognitive disorders are the most common neuropsychiatric disorders in later life. Their co-occurrence most likely exceeds chance.